Adjuvant treatment with a L-alanyl-L-glutamine supplementation in dogs with parvoviral enteritis

Glutamine has been used to treat canine patients with parvoviral enteritis. However, little is known about the effect of L-alanyl-L-glutamine (Ala-Gln) supplementation in dogs The objective this study was determine whether Ala-Gln can improve dog survival and ameliorate clinical signs without adverse effects. We conducted a randomized, double-blind, placebo-controlled trial involving 39 client-owned dogs. were randomly assigned two groups administered either an solution (Dipeptiven, 0.4 g/kg, n = 20) or equivalent volume placebo (n 19) orally twice daily. Of dogs, 17 vaccinated 9 Ala-Gln-treated group – group). All received standard treatment while hospitalized. monitored according scoring system evaluated diagnostically daily for 11 days. Survival rates both quantified using Kaplan‒Meier curves statistically compared log-rank test. total score did not differ between groups, except on day 2. differed significantly (p=0.038). Three (15.0%) died during study, whereas eight (42.1%). No effects found be associated treatment. Oral administration improves enteritis causing